OP in this context would be 'original poster'.
Further up, I poked a bit of fun at Nzane, it was just that, a bit of fun. If you read Nzane's comments on this entire website, he is nothing but helpful, diligent, informative, and also quite funny too. I like reading his posts, and I've learned a lot from his contributions.
I don't mean any negativity with what I post. I enjoy this community and Nzane is a good, good contributor.
Going back to the issue at hand, I can totally understand the frustration of the OP and their continued efforts to make their game stable, but it is what it is.
You could have the most powerful machine on the planet, capapble of running the world's economy, but the game engine of Fallout4 is still a delicate and some might say poorly written/optimized thing, and it will CTD at seemingly random times, doing random things.
The best way I have found, to make this game run, is to run it within certain boundaries.
For example, if you run the game and build no cities to begin with, and that game starts stable, then you can take a hard save at that point, and you can always revert back to that hard save, knowing that you can go again.
I also take a lot of hard saves at certain points, like I make a hard save every time my character levels up.
I never add or remove mods during a play through. I do mark mods I see (thanks Raybo), for the next game, and I also look to remove mods that are possibly unsupported and have many issues (a good example of one such mod in this context is the minuteman faction pack which came out very early, had a lot of problems and has hardly been touched by the author since).
I don't have the most powerful machine, I know the limitations of the machine and of my game and I adapt to that. Because of these constraints I impose on myself I have just played a game where I have gone through 100 levels with minimal issues;
issue #1 - an internal plot type had a problem. It was diagnosed by Kinggath and the team, a correction made, I continued on with the game and all is good.
issue #2 - bloodworms in mulligans mine caused the infinite load screen. I detailed this in these forums, provided a workaround and all is good.
That is it. That is the sum total of the issues I have faced in 100+ levels.
Now, I admit, I am not using Conqueror in the play through (see minuteman faction issues above), but I have it installed and kept it up to date as I do with all my mods.
For my next play through, I fully intend to run with Conqueror, and I will do what I do for all my games.
1. Start with no mods except UFO4P installed.
2. Select minimal options to get conqueror up and running. Including not building any of sanctuary, red rocket or abernathy. I will not build on spectacle island, nor in any settlement that comes with a terminal, such as Sunshine Tidings and/or Red Rocket (I like the lore). I won't use Starlight Drive-in, nor Hangman's Alley because of instability and performance issues, and I won't use any settlement that has quests around it, like The Castle, so from the get-go I have already imposed a strict set of rules on my play through.
3. Save just before I leave the vault.
4. Quit at that point, enable the mods I want to run with (no creation club mods except for a furniture pack I bought).
5. Start the game and make another hard save directly after all mods have loaded.
at that point I will have a choice. Go to Concorde and side with Jammer, or don't. I won't kill the Quincy 5, as that action breaks the game in weird places (ref Sturges being dead means you can't destroy the Institute).
All of the steps above is pretty much what I do for games, and now I've added some steps to include Conqueror, based on issues that have come to light in these forums and elsewhere.
I hope some of this helps the OP, and anyone else who's read this far.