I run in 3440x1440 and use
TRUBY9 ULTRAWIDE - FALLOUT 4
I had issues, like some of the SS2 HUDs not being on screen in the lower third or nearly half the right side, but it's just a matter of configuring the hot keys to shift them across so they are in the visible 'window' for the HUD boxes (other things like message boxes and the like are fine to show anywhere on screen). I think I had better results using some of the FallUI mods but I have been almost exclusively on my city plan contest build profile for the last 5 months which doesn't have FallUI configured (or many mods at all execpt add-ons) so am a bit hazy on my memory.